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Comment
. 2010 Mar 3;11(3):175-6.
doi: 10.1016/j.cmet.2010.02.009.

The FOX(O1) blasts off

Deborah Veis Novack  1
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The FOX(O1) blasts off

Deborah Veis Novack. Cell Metab. .
Free article

Abstract

Systemic glucose homeostasis is primarily regulated by insulin, which targets liver, fat, and skeletal muscle cells, setting up important feedback loops. New studies now show that the osteoblast also has a significant role in modulating systemic insulin responses, via the insulin-regulated transcription factor FOXO1 and the hormone osteocalcin.

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