Comment
doi: 10.1016/j.cmet.2010.02.011.
Peptides signal mitochondrial stress
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- PMID: 20197049
- DOI: 10.1016/j.cmet.2010.02.011
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Comment
Peptides signal mitochondrial stress
Cell Metab.
.
Free article
Abstract
The unfolded protein response (UPR(mt)) rebalances mitochondrial protein homeostasis upon proteotoxic perturbations. Haynes et al. (2010) show that this retrograde stress signal is based on efflux of peptides derived from damaged proteins from the mitochondrial matrix to the cytosol; this initiates downstream protective responses in the nucleus to restore cellular balance.
Copyright 2010 Elsevier Inc. All rights reserved.
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