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Comment
. 2010 Mar 3;11(3):177-8.
doi: 10.1016/j.cmet.2010.02.011.

Peptides signal mitochondrial stress

Janine Kirstein-Miles  1 , Richard I Morimoto
Affiliations
Free article
Comment

Peptides signal mitochondrial stress

Janine Kirstein-Miles et al. Cell Metab. .
Free article

Abstract

The unfolded protein response (UPR(mt)) rebalances mitochondrial protein homeostasis upon proteotoxic perturbations. Haynes et al. (2010) show that this retrograde stress signal is based on efflux of peptides derived from damaged proteins from the mitochondrial matrix to the cytosol; this initiates downstream protective responses in the nucleus to restore cellular balance.

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