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. 2010 Mar 3;11(3):179-81.
doi: 10.1016/j.cmet.2010.02.004.

New uses for old drugs: neonatal diabetes and sulphonylureas

Frances M Ashcroft  1
Affiliations
Free article

New uses for old drugs: neonatal diabetes and sulphonylureas

Frances M Ashcroft. Cell Metab. .
Free article

Abstract

The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy.

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