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Case Reports
. 2010;53(3):183-7.
doi: 10.1159/000289342. Epub 2010 Mar 3.

Immunocompromised patients with HBsAg a determinant mutants: comparison of HBsAg diagnostic assays

E Veropalumbo  1 , A Marrone, L Vallefuoco, G Perruolo, R Orlando, F Scordino, G Tosone, R Zampino, B Trani, A Genovese, G Spadaro, C D'Orio, G Portella
Affiliations
Case Reports

Immunocompromised patients with HBsAg a determinant mutants: comparison of HBsAg diagnostic assays

E Veropalumbo et al. Intervirology. 2010.

Abstract

Hepatitis B surface antigen (HBsAg) is considered the best marker for the diagnosis of hepatitis B virus (HBV) infection. Mutations of the s gene involving amino acid substitutions within the a determinant could affect the sensitivity of diagnostic tests. In the present study, HBsAg mutants were detected in 3 immunocompromised patients, previously found to be HBsAg negative and anti-HBs positive. All patients had high levels of HBV-DNA, whereas HBsAg tests gave discordant results. Immunosuppression can cause viral reactivation of occult HBV infection in these patients and favour the selection of HBsAg a determinant mutants.

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