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. 2009 Winter;14(4):45-9.

Effects of nebivolol versus bisoprolol on endothelial function in hypertensive patients

Iana Ivaylova Simova  1 , Rumiana Radoslavova Todorova-Konstantinova, Stefan Veselinov Denchev
Affiliations

Effects of nebivolol versus bisoprolol on endothelial function in hypertensive patients

Iana Ivaylova Simova et al. Exp Clin Cardiol. 2009 Winter.

Abstract

Objective: To determine the effects of two beta-blockers, nebivolol and bisoprolol, on endothelial function in newly diagnosed hypertensive patients.

Methods: Twenty-five hypertensive patients with a mean (+/- SD) age of 45.3+/-11.5 years were randomly assigned to receive either nebivolol or bisoprolol for eight weeks in an open-label, crossover design. Flow-mediated endothelial-dependent vasodilation (FMD) was measured at baseline and after each eight-week treatment period. At the end of each treatment period, 24 h ambulatory blood pressure (BP) monitoring was performed.

Results: The effect of the two beta-blockers on BP was similar. The mean FMD before initiation of treatment was 4.14+/-3.55%. After treatment with nebivolol, FMD increased to 8.99+/-4.21%, with a statistically significant difference from baseline (P<0.001). The effect of bisoprolol treatment on FMD was not as dramatic (3.72+/-6.84%), with no statistically significant difference from baseline. Comparing FMD after each therapeutic regimen, nebivolol treatment resulted in a marked increase in the reactivity of the brachial artery (ie, improvement of endothelial function) compared with bisoprolol treatment (P<0.001).

Conclusion: Nebivolol treatment of untreated hypertensive patients led to a significant improvement in endothelial function compared with bisoprolol treatment, despite the similar effect on BP with either therapeutic agent.

Keywords: Arterial hypertension; Bisoprolol; Endothelial function; Flow-mediated dilation; Nebivolol.

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Figures

Figure 1)
Figure 1)
Flow diagram of the study. FMD Flow-mediated endothelial-dependent vasodilation; 24-h ABPM 24 h ambulatory blood pressure monitoring
Figure 2)
Figure 2)
Mean flow-mediated endothelial-dependent vasodilation (FMD) values with 95% CI at baseline and after eight weeks of treatment with nebivolol and bisoprolol
See this image and copyright information in PMC

References

    1. Mancia G, De Backer G, Dominiczak A, et al. European Society of Hypertension; European Society of Cardiology 2007 ESH-ESC Guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) Blood Press. 2007;16:135–232. - PubMed
    1. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111–5. - PubMed
    1. Ercan E, Tengiz I, Ercan HE, Nalbantgil I. Left ventricular hypertrophy and endothelial functions in patients with essential hypertension. Coron Artery Dis. 2003;14:541–4. - PubMed
    1. Millgard J, Lind L. Acute hypertension impairs endothelium-dependent vasodilation. Clin Sci (Lond) 1999;96:217–8. - PubMed
    1. Palmieri V, Storto G, Arezzi E, et al. Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects. J Hum Hypertens. 2005;19:941–50. - PubMed

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