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Editorial
. 2010 Mar;51(3):737-40.
doi: 10.1002/hep.23529.

The epithelial-to-mesenchymal transition in liver fibrosis: here today, gone tomorrow?

Rebecca G Wells
Editorial

The epithelial-to-mesenchymal transition in liver fibrosis: here today, gone tomorrow?

Rebecca G Wells. Hepatology. 2010 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic showing the use of lineage tracing to study hepatocyte EMT. The upper left shows the two crosses required to generate the triple transgenic mice used by Taura et al. (12). The group carried out three experiments using these animals, #1 with cells isolated from normal livers and #s 2 and 3 with cells and tissues, respectively, from fibrotic livers. The predicted findings in the absence or presence of EMT are shown; the actual findings of Taura et al. are indicated in red, illustrating that there was no EMT observed in the fibrosis model. Aqua indicates cells co-expressing β-galactosidase and GFP, consistent with EMT having occurred. Not shown is the heterogeneity in hepatocyte labeling with β-galactosidase
See this image and copyright information in PMC

Comment on

References

    1. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest. 2002;110:341–350. - PMC - PubMed
    1. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995;130:393–405. - PMC - PubMed
    1. Choi SS, Diehl AM. Epithelial-to-mesenchymal transitions in the liver. Hepatology. 2009;50:2007–2013. - PMC - PubMed
    1. Parola M, Pinzani M. Hepatic wound repair. Fibrogenesis Tissue Repair. 2009;2:4. - PMC - PubMed
    1. Willis BC, Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:L525–534. - PubMed