[Association between the tryptophan hydroxylase (TPH) gene polymorphic markers and endogenous psychoses]

Abstract

Tryptophan hydroxylase is one of the key enzymes involved in serotonergic metabolism. In many studies, an association between the TPH gene and human mentality, as well as mental disorder was demonstrated. This study was designed to analyze the association between three TPH gene polymorphisms (A218C, T3792A, and (CT)n(CA)n(CT)n) and endogenous psychoses. The patients included into investigation were represented by those with manic-depressive psychosis (93 individuals) and those with the schizophrenia spectrum disorders (307 individuals). An association between the A218C polymorphism with the disorders of the schizophrenia spectrum was demonstrated. These findings confirmed the data obtained earlier for other populations. In addition, an association between the (CT)n(CA)n(CT)n microsatellite repeats and bipolar disease was shown for the first time.