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. 2011 Jan;123(1):48-53.
doi: 10.1111/j.1600-0404.2010.01343.x.

Acute postoperative seizures after epilepsy surgery - a long-term outcome predictor?

K Å Alfstad  1 , M I Lossius, G K Røste, P Mowinckel, D Scheie, O C Borota, P G Larsson, K O Nakken
Affiliations

Acute postoperative seizures after epilepsy surgery - a long-term outcome predictor?

K Å Alfstad et al. Acta Neurol Scand. 2011 Jan.

Abstract

Objectives: The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post-surgery, as a predictor of long-term seizure outcome, and investigated the utility of other potential outcome predictors.

Materials and methods: Medical records of 48 patients with temporal and extra-temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow-up.

Results: At 2 year follow-up, 25 patients (53%) were seizure free. Univariate analysis showed that APS (P = 0.048), using ≥ six AEDs prior to surgery (P = 0.03), pathological postoperative EEG (P = 0.043) and female gender (P = 0.012) were associated with seizure recurrence.

Conclusions: Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained significance in the multivariate analysis.

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