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Clinical Trial
. 2010 Apr 19;28(18):3086-94.
doi: 10.1016/j.vaccine.2010.02.065. Epub 2010 Mar 1.

Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

F M Russell  1 , P V Licciardi, A Balloch, V Biaukula, L Tikoduadua, J R Carapetis, J Nelson, A W J Jenney, L Waqatakirewa, S Colquhoun, Y B Cheung, M L K Tang, E K Mulholland
Affiliations
Clinical Trial

Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

F M Russell et al. Vaccine. .

Abstract

Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p<0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group.

Trial registration: ClinicalTrials.gov NCT00170612.

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Figure 1
Figure 1. CONSORT chart of the screened and enrolled children to 17 months of age
See this image and copyright information in PMC

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