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Review
. 2010 Jun;44(6):301-7.
doi: 10.1677/JME-09-0143. Epub 2010 Mar 3.

Adrenocortical development and cancer: focus on SF-1

Enzo Lalli  1
Affiliations
Review

Adrenocortical development and cancer: focus on SF-1

Enzo Lalli. J Mol Endocrinol. 2010 Jun.

Abstract

Steroidogenic factor-1 (SF-1/Ad4-binding protein; NR5A1) is an essential regulator of tissue-specific gene expression in steroidogenic cells and of adrenogonadal development. Here, I discuss recent data in the literature showing the implication of SF-1 and the importance of its dosage not only during development but also for adrenal cortex tumorigenesis in humans and mice.

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