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Review
. 2010 Mar;40(3):611-5.
doi: 10.1002/eji.200940180.

Inflammasomes as microbial sensors

Luigi Franchi  1 , Raul Muñoz-Planillo, Thornik Reimer, Tatjana Eigenbrod, Gabriel Núñez
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Free article
Review

Inflammasomes as microbial sensors

Luigi Franchi et al. Eur J Immunol. 2010 Mar.
Free article

Abstract

Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.

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