Pyroptosis - a cell death modality of its kind?
- PMID: 20201017
- DOI: 10.1002/eji.200940160
Pyroptosis - a cell death modality of its kind?
Abstract
The term "pyroptosis" was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis - which can also be triggered by non-bacterial pathological stimuli - truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.
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