Review
doi: 10.1002/eji.200940039.
The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
Affiliations
- PMID: 20201020
- DOI: 10.1002/eji.200940039
Item in Clipboard
Review
The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
Eur J Immunol.
2010 Mar.
Free article
Abstract
Alum has been the only adjuvant licensed for human vaccines for decades and is still widely used, but its mechanism of action remains obscure. Recently, the NLRP3 inflammasome has been linked to the immunostimulatory properties of alum and other particulate adjuvants, although it is disputed to what degree NLRP3 is genuinely essential in vivo. Meanwhile, researchers are testing adjuvants harnessing both the infectious/non-infectious-discriminating TLR and the danger-sensing NLRP3 inflammasome pathways. Could this be the basis of a long-needed rationale in the design of adjuvants?
Similar articles
-
The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants.Eur J Immunol. 2010 Mar;40(3):634-8. doi: 10.1002/eji.200940172. Eur J Immunol. 2010. PMID: 20201019 Review.
-
Mechanism of action of licensed vaccine adjuvants.Vaccine. 2009 May 26;27(25-26):3331-4. doi: 10.1016/j.vaccine.2009.01.084. Epub 2009 Feb 5. Vaccine. 2009. PMID: 19200813
-
Regulation of adaptive immunity by the NLRP3 inflammasome.Int Immunopharmacol. 2011 May;11(5):549-54. doi: 10.1016/j.intimp.2010.11.025. Epub 2010 Nov 27. Int Immunopharmacol. 2011. PMID: 21118671 Review.
-
Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants.Immunol Cell Biol. 2014 Jul;92(6):535-42. doi: 10.1038/icb.2014.21. Epub 2014 Apr 1. Immunol Cell Biol. 2014. PMID: 24687021 Clinical Trial.
-
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.Nature. 2008 Jun 19;453(7198):1122-6. doi: 10.1038/nature06939. Epub 2008 May 21. Nature. 2008. PMID: 18496530 Free PMC article.
Cited by
-
Novel adjuvants in allergen-specific immunotherapy: where do we stand?Front Immunol. 2024 Feb 23;15:1348305. doi: 10.3389/fimmu.2024.1348305. eCollection 2024. Front Immunol. 2024. PMID: 38464539 Free PMC article. Review.
-
Mucosal vaccine adjuvants update.Clin Exp Vaccine Res. 2012 Jul;1(1):50-63. doi: 10.7774/cevr.2012.1.1.50. Epub 2012 Jul 31. Clin Exp Vaccine Res. 2012. PMID: 23596577 Free PMC article.
-
Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response.Sci Immunol. 2022 May 6;7(71):eabk0018. doi: 10.1126/sciimmunol.abk0018. Epub 2022 May 6. Sci Immunol. 2022. PMID: 35522725 Free PMC article.
-
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.Front Pharmacol. 2020 Sep 15;11:581011. doi: 10.3389/fphar.2020.581011. eCollection 2020. Front Pharmacol. 2020. PMID: 33041826 Free PMC article.
-
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.J Biol Chem. 2013 Mar 15;288(11):7481-7491. doi: 10.1074/jbc.M112.400655. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23297415 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
