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. 2010 Mar;16(3):507-10.
doi: 10.3201/eid1603.091346.

Experimental infection of squirrel monkeys with nipah virus

Philippe Marianneau  1 , Vanessa Guillaume, Thong Wong, Munisamy Badmanathan, Ren Yih Looi, Severine Murri, Philippe Loth, Noel Tordo, Fabian Wild, Branka Horvat, Hugues Contamin
Affiliations

Experimental infection of squirrel monkeys with nipah virus

Philippe Marianneau et al. Emerg Infect Dis. 2010 Mar.

Abstract

We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.

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Figures

Figure
Figure
Pathologic signs associated with Nipah virus infection in squirrel monkeys. A) Focal inflammation in the lung (monkey B). Hematoxylin and eosin stains; original magnification ×10. B) Viral antigens (brown staining) were immunolocalized to the alveolar walls (monkey E). C) brain neuron (monkey B). D) Tubular and extratubular cells in the kidney (monkey E). E) Lymphoid cells in the spleen (monkey D). B–E, immunoperoxidase stains, original magnification ×20.
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