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Editorial
. 2010 Mar 5;106(4):627-9.
doi: 10.1161/CIRCRESAHA.109.215855.

Polyphenols and cholesterol efflux: is coffee the next red wine?

Megan F Burke, Amit V Khera, Daniel J Rader
Editorial

Polyphenols and cholesterol efflux: is coffee the next red wine?

Megan F Burke et al. Circ Res. .
No abstract available

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Figures

Figure 1
Figure 1
Postulated Mechanisms for effects of polyphenols on macrophage cholesterol efflux. Cholesterol is effluxed out of macrophage foam cells in the first step of reverse cholesterol transport (RCT). Efflux to lipid-free or lipid-poor Apo-A1 particles (which then become mature HDL) occurs via the ATP-binding cassette subfamily A1 (ABCA1) transporter, while efflux directly to mature HDL particles occurs via the ATP-binding cassette subfamily G1 (ABCG1) transporter. Resveratrol and anthocyanins promote the efflux pathway via upregulation of liver X receptor (LXR)., Uto-Kondo et al demonstrated that two phenolic acids, as well as whole coffee, increased both mRNA and protein levels of ABCG1 and scavenger receptor class B type I (SR-BI), but not ABCA1, by enhancing mRNA stability.
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