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Case Reports
. 2010 Mar;7(3):174-7.
doi: 10.1038/nrgastro.2010.7.

Rash induced by anti-tumor necrosis factor agents in an adolescent with Crohn's disease

Laurie S Conklin  1 , Bernard Cohen, Lindsay Wilson, Carmen Cuffari, Maria Oliva-Hemker
Affiliations
Case Reports

Rash induced by anti-tumor necrosis factor agents in an adolescent with Crohn's disease

Laurie S Conklin et al. Nat Rev Gastroenterol Hepatol. 2010 Mar.

Abstract

Background: A 17-year-old white male with Crohn's disease who was receiving maintenance infusions of the anti-tumor necrosis factor (TNF) agent, infliximab, presented with a new-onset psoriasiform skin rash. The rash was not responsive to topical or oral corticosteroids and worsened after infliximab infusions and after subsequent administration of a second anti-TNF drug, adalimumab.

Investigations: Full medical history and physical examination, including assessment of the morphology of rash and the temporal correlation with administration of anti-TNF agents.

Diagnosis: Anti-TNF-agent induced psoriasiform skin rash.

Management: Discontinuation of anti-TNF therapy. The patient opted to have his gastrointestinal symptoms treated with oral mesalazine and metronidazole.

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References

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