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Review
. 2010 Mar;13(2):235-46.

Novel therapeutics for Alzheimer's disease: an update

David J Bonda  1 , Hyun-Pil Lee, Hyoung-gon Lee, Avi L Friedlich, George Perry, Xiongwei Zhu, Mark A Smith
Affiliations
Review

Novel therapeutics for Alzheimer's disease: an update

David J Bonda et al. Curr Opin Drug Discov Devel. 2010 Mar.

Abstract

As the most prevalent form of dementia worldwide, Alzheimer's disease (AD) continues to be a burden for patients and their families. In addition, with the global population of aged individuals increasing exponentially, AD represents a significant economic burden to society. The development of an effective approach for the treatment of AD is thus of major importance, as current treatment strategies are limited to agents that attenuate disease symptomatology without addressing the causes of disease. A considerable need exists for the development of an effective therapy to prevent, or at least delay, the progression of AD. Current hypotheses for the pathogenesis of AD are discussed in this review, with a particular emphasis on the implications of these hypotheses with respect to treatment strategies and preventive measures.

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