doi: 10.1021/jo100105k.
1,3-Dipolar cycloaddition reactions of vinylidenecyclopropane-diesters with aromatic diazomethanes generated in situ
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- PMID: 20205439
- DOI: 10.1021/jo100105k
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1,3-Dipolar cycloaddition reactions of vinylidenecyclopropane-diesters with aromatic diazomethanes generated in situ
J Org Chem.
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Abstract
1,3-Dipolar cycloaddition reactions of VDCP-diesters with aromatic diazomethanes generated in situ from the corresponding aromatic aldehydes and tosylhydrazine mediated by base produce pyrazole derivatives in good yields under mild conditions. A plausible reaction mechanism has been proposed on the basis of control experiments along with the discussion on the regioselectivity.
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