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. 2010 Apr 2;75(7):2296-301.
doi: 10.1021/jo100105k.

1,3-Dipolar cycloaddition reactions of vinylidenecyclopropane-diesters with aromatic diazomethanes generated in situ

Lei Wu  1 , Min Shi
Affiliations

1,3-Dipolar cycloaddition reactions of vinylidenecyclopropane-diesters with aromatic diazomethanes generated in situ

Lei Wu et al. J Org Chem. .

Abstract

1,3-Dipolar cycloaddition reactions of VDCP-diesters with aromatic diazomethanes generated in situ from the corresponding aromatic aldehydes and tosylhydrazine mediated by base produce pyrazole derivatives in good yields under mild conditions. A plausible reaction mechanism has been proposed on the basis of control experiments along with the discussion on the regioselectivity.

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