doi: 10.1021/ol1001544.
Synthesis of 2-indolylphosphines by palladium-catalyzed annulation of 1-alkynylphosphine sulfides with 2-iodoanilines
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- PMID: 20205465
- DOI: 10.1021/ol1001544
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Synthesis of 2-indolylphosphines by palladium-catalyzed annulation of 1-alkynylphosphine sulfides with 2-iodoanilines
Org Lett.
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Abstract
Palladium-catalyzed annulation of 1-alkynylphosphine sulfides with 2-iodoanilines followed by desulfidation affords 3-substituted 2-indolylphosphines. This annulation/desulfidation sequential protocol offers a conceptually new approach to bulky heteroarylphosphines.
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