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Host determinants of HIV-1 control in African Americans

Kimberly Pelak et al. J Infect Dis. .

Erratum in

  • J Infect Dis. 2010 Aug 15;202(3):501

Abstract

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

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Conflict of interest statement

Conflict of Interest: The authors do not have any commercial or other association that might pose a conflict of interest.

Figures

Figure 1
Figure 1. Distribution of mean viral load (VL) setpoint according to genotype
The direction of the effect of the rs2523608 genotype is consistent in A) African Americans and B) Europeans. C) Samples with HLA-B*5703 have a lower HIV-1 viral load setpoint.
Figure 2
Figure 2. Average linkage disequilibrium (LD) in the MHC region in people of European descent versus African Americans
The average D′ and the average r2 are both shorter in the African American genome as compared to the European genome.
See this image and copyright information in PMC

Comment in

References

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