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Review
. 2009 Nov 1;9(13):1527-37.
doi: 10.2174/138955709790361557.

Mechanisms of the resistance and tolerance to beta-lactam and glycopeptide antibiotics in pathogenic gram-positive cocci

A Mlynarczyk  1 , B Mlynarczyk, M Kmera-Muszynska, S Majewski, G Mlynarczyk
Affiliations
Review

Mechanisms of the resistance and tolerance to beta-lactam and glycopeptide antibiotics in pathogenic gram-positive cocci

A Mlynarczyk et al. Mini Rev Med Chem. .

Abstract

Beta-lactams are the most frequently used antimicrobials in combating infections. In the case of gram-positive bacteria resistant to beta-lactams, glycopeptides are the first choice. The occurrence, mechanisms and genetic background of the resistance of pathogenic staphylococci, streptococci and enterococci to beta-lactam and glycopeptide antibiotics were discussed. The resistances to well-established antimicrobials, as well as new agents (ceftobiprole, oritavancin, telavancin, dalbavancin) were taken into consideration in the text.

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