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. 2010 Feb 1:3:41.
doi: 10.1186/1757-1626-3-41.

Adenosquamous carcinoma of the pancreas: a case report

Evangelia Skafida  1 , Xanthippi Grammatoglou, Chryssoula Glava, Dimitrios Zissis, Nikolaos Paschalidis, Eleftheria Katsamagkou, Nikolaos Firfiris, Thivi Vasilakaki
Affiliations

Adenosquamous carcinoma of the pancreas: a case report

Evangelia Skafida et al. Cases J. .

Abstract

Adenosquamous carcinoma of the pancreas is a rare variant of pancreatic exocrine carcinoma. We report a case of 70 year old man who came to our hospital with abdominal pain, anorexia and jaundice. Imaging of the abdomen showed a mass in the region of the head of the pancreas. Histological evaluation of the pancreatic tumor showed an adenosquamous carcinoma which was extensively infiltrative with perineural invasion, involvement of peripancreatic lymph nodes and all the thickness of the duodenum wall. The tumor exhibited a biphasic malignant growth identified as well to moderate differentiated adenocarcinoma and well to poorly differentiated squamous cell carcinoma.

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Figures

Figure 1
Figure 1
Adenosquamous carcinoma of the pancreas with area of necrosis (H&E × 20).
Figure 2
Figure 2
Adenosquamous carcinoma of the pancreas (H&E × 40).
Figure 3
Figure 3
Adenocarcinoma similar to ductal carcinoma (H&E × 100).
Figure 4
Figure 4
Squamous cell carcinoma composed of irregular nests of polygonal cells with no gland formation (H&E × 200).
Figure 5
Figure 5
Lymph node metastasis only from the squamous element (H&E × 100).
Figure 6
Figure 6
Ker7 showed predilection for adenocarcinoma (Ker 7 × 100).
Figure 7
Figure 7
The squamous component was strongly immunoreactive with CK5/6, while the glandular component was negative (CK5/6 × 100).
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