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Review
. 2010 Aug;21(6):609-15.
doi: 10.1016/j.semcdb.2010.02.010. Epub 2010 Mar 3.

Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans

Harry Schachter  1
Affiliations
Review

Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans

Harry Schachter. Semin Cell Dev Biol. 2010 Aug.

Abstract

UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms. This review describes the effects of mutations in the Mgat1 gene on the development of Caenorhabditis elegans, Drosophila melanogaster and mice.

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