Cardiac rhabdomyoma: a clinicopathologic study
- PMID: 2020664
Cardiac rhabdomyoma: a clinicopathologic study
Abstract
We studied the clinical and pathologic features of 17 cardiac rhabdomyomas from 13 males and four females whose ages ranged from birth to 9 yr (mean, 36 wk). Eleven were multiple, and tumors were found throughout the heart. Four patients had congenital heart disease, and three had tuberous sclerosis; of the ten sporadic cases, four were surgical resections. Three of the four patients with surgical resections survived postoperatively. Two patients presented with sudden cardiac death. Immunohistochemical stains on seven tumor revealed diffuse positivity for myoglobin, actin, desmin, and vimentin, with negative results for S-100 protein, similar to adjacent cardiac muscle. We conclude that cardiac rhabdomyomas can be sporadic, can be associated with tuberous sclerosis, or can be seen with other cardiac malformations. They usually present early in life with a variety of symptoms, including sudden death, and attempts at resection may be successful.
Similar articles
-
[Cardiac rhabdomyomas and aortic valve atresia: an unusual association].Ann Pathol. 1986;6(3):206-10. Ann Pathol. 1986. PMID: 3778586 French.
-
Cardiac rhabdomyoma associated with tuberous sclerosis. An autopsy case of newborn infant died of cardiac failure.Acta Pathol Jpn. 1987 Apr;37(4):645-53. Acta Pathol Jpn. 1987. PMID: 3618225
-
[Cardiac rhabdomyoma in children and Bourneville's tuberous sclerosis].Arch Mal Coeur Vaiss. 1990 May;83(5):673-80. Arch Mal Coeur Vaiss. 1990. PMID: 2114082 Review. French.
-
Incidental cardiac rhabdomyomas: a significant finding necessitating additional investigation at the time of autopsy.J Forensic Sci. 1991 Jul;36(4):1229-33. J Forensic Sci. 1991. PMID: 1919480
-
Incidence of tuberous sclerosis in patients with cardiac rhabdomyoma.Am J Med Genet. 1990 Dec;37(4):443-6. doi: 10.1002/ajmg.1320370402. Am J Med Genet. 1990. PMID: 2260584 Review.
Cited by
-
Mediastinal rhabdomyoma: case report and review of the literature.Virchows Arch. 2006 Jul;449(1):124-8. doi: 10.1007/s00428-006-0211-8. Epub 2006 Apr 25. Virchows Arch. 2006. PMID: 16636850
-
Neoplasms involving the heart, their simulators, and adverse consequences of their therapy.Proc (Bayl Univ Med Cent). 2001 Oct;14(4):358-76. doi: 10.1080/08998280.2001.11927789. Proc (Bayl Univ Med Cent). 2001. PMID: 16369647 Free PMC article.
-
The pathogenesis of so-called cardiac rhabdomyoma in swine: a histological, immunohistochemical and ultrastructural study.Virchows Arch. 1995;427(2):213-21. doi: 10.1007/BF00196528. Virchows Arch. 1995. PMID: 7582253
-
Giant right atrial cystic hamartoma: a case report and literature review.BMJ Case Rep. 2009;2009:bcr02.2009.1587. doi: 10.1136/bcr.02.2009.1587. Epub 2009 Jun 1. BMJ Case Rep. 2009. PMID: 21686985 Free PMC article.
-
Cardiac rhabdomyoma: an uncommon culprit in sudden infant death.Forensic Sci Med Pathol. 2024 Sep;20(3):977-982. doi: 10.1007/s12024-023-00737-9. Epub 2024 Jul 4. Forensic Sci Med Pathol. 2024. PMID: 38963610 Free PMC article.