doi: 10.1016/j.bmcl.2010.02.058.
Epub 2010 Feb 19.
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist
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- PMID: 20207541
- DOI: 10.1016/j.bmcl.2010.02.058
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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist
Bioorg Med Chem Lett.
.
Abstract
We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.
2010 Elsevier Ltd. All rights reserved.
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