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. 2010 Apr 1;20(7):2106-10.
doi: 10.1016/j.bmcl.2010.02.058. Epub 2010 Feb 19.

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Shuwen He  1 , Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L Franklin, Raman K Bakshi, James P Dellureficio, Qingmei Hong, Nancy N Tsou, Richard G Ball, Doreen E Cashen, William J Martin, David H Weinberg, Tanya Macneil, Rui Tang, Constantin Tamvakopoulos, Qianping Peng, Randy R Miller, Ralph A Stearns, Howard Y Chen, Airu S Chen, Alison M Strack, Tung M Fong, D Euan Macintyre, Matthew J Wyvratt Jr, Ravi P Nargund
Affiliations

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Shuwen He et al. Bioorg Med Chem Lett. .

Abstract

We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.

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