Review
doi: 10.1271/bbb.90678.
Epub 2010 Mar 7.
Studies of the structure-activity relationships of peptides and proteins involved in growth and development based on their three-dimensional structures
Affiliations
- PMID: 20208353
- DOI: 10.1271/bbb.90678
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Review
Studies of the structure-activity relationships of peptides and proteins involved in growth and development based on their three-dimensional structures
Biosci Biotechnol Biochem.
2010.
Free article
Abstract
Peptides and proteins with similar amino acid sequences can have different biological functions. Knowledge of their three-dimensional molecular structures is critically important in identifying their functional determinants. In this review, I describe the results of our and other groups' structure-based functional characterization of insect insulin-like peptides, a crustacean hyperglycemic hormone-family peptide, a mammalian epidermal growth factor-family protein, and an intracellular signaling domain that recognizes proline-rich sequence.
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