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. 2010;74(3):663-6.
doi: 10.1271/bbb.90764. Epub 2010 Mar 7.

Pro-oxidant action of pyrroloquinoline quinone: characterization of protein oxidative modifications

Takeshi Ishii  1 , Mitsugu Akagawa, Yuji Naito, Osamu Handa, Tomohisa Takagi, Taiki Mori, Shigenori Kumazawa, Toshikazu Yoshikawa, Tsutomu Nakayama
Affiliations
Free article

Pro-oxidant action of pyrroloquinoline quinone: characterization of protein oxidative modifications

Takeshi Ishii et al. Biosci Biotechnol Biochem. 2010.
Free article

Abstract

Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.

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