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Review
. 2010 Jan;8(1):73-80.
doi: 10.2174/157016210790416389.

Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV

John H Elder  1 , Ying-Chuan Lin, Elizabeth Fink, Chris K Grant
Affiliations
Review

Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV

John H Elder et al. Curr HIV Res. 2010 Jan.

Abstract

FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.

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Figures

Figure 1
Figure 1
Schematic diagram of the FIV SU, showing Variable (V) loops predicted from comparisons of multiple FIV Env sequences. Boxed areas in the structure indicate relative locations of the epitopes for a panel of monoclonal antibodies generated in mice using whole virions and mapped using nested synthetic peptides and deletion constructs (,; unpublished data)
See this image and copyright information in PMC

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