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. 2010 Jul;76(1):31-4.
doi: 10.1111/j.1399-0039.2010.01460.x. Epub 2010 Mar 1.

African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity

L Hou  1 , M Chen, B Jiang, J Ng, C K Hurley
Affiliations

African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity

L Hou et al. Tissue Antigens. 2010 Jul.

Abstract

KIR2DL1 alleles were identified by DNA sequencing of the coding region from amplified genomic DNA from 100 random African Americans. The majority of individuals (97%) carried a KIR2DL1 locus. Allele KIR2DL1*00302 was found in 68% of individuals but KIR2DL1*00401, *002, *00303, *006, and *007 were also frequent. Eleven new alleles were described: KIR2DL1*00403, *01101, *01102, *012, *013N, *014, *015, *016, *017, *018, and *019. Nine of the novel alleles encoded amino acid substitutions located throughout the receptor; one allele carried a stop codon in the exon encoding the first extracellular domain.

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Figures

Figure 1
Figure 1
Phylogenetic tree of KIR2DL1 alleles. Alleles shown in red were described in this study. Previously described KIR2DL1*005 was not included because it is missing a portion of the nucleotide sequence encoding the signal peptide.
See this image and copyright information in PMC

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