PRDM9 points the zinc finger at meiotic recombination hotspots
- PMID: 20210982
- PMCID: PMC2872867
- DOI: 10.1186/gb-2010-11-2-104
PRDM9 points the zinc finger at meiotic recombination hotspots
Abstract
Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.
Comment on
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PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.Science. 2010 Feb 12;327(5967):836-40. doi: 10.1126/science.1183439. Epub 2009 Dec 31. Science. 2010. PMID: 20044539 Free PMC article.
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