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. 2010 Mar 5;140(5):601-5.
doi: 10.1016/j.cell.2010.02.017.

Membrane curvature in synaptic vesicle fusion and beyond

Harvey T McMahon  1 , Michael M Kozlov, Sascha Martens
Affiliations

Membrane curvature in synaptic vesicle fusion and beyond

Harvey T McMahon et al. Cell. .

Abstract

Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.

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