Comment
doi: 10.1016/j.cell.2010.02.020.
Preview. MicroRNAs: from decay to decoy
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- PMID: 20211130
- DOI: 10.1016/j.cell.2010.02.020
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Preview. MicroRNAs: from decay to decoy
Cell.
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Abstract
MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation.
(c) 2010 Elsevier Inc. All rights reserved.
Comment on
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miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.Cell. 2010 Mar 5;140(5):652-65. doi: 10.1016/j.cell.2010.01.007. Cell. 2010. PMID: 20211135 Free PMC article.
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