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. 2010 May;54(5):2235-8.
doi: 10.1128/AAC.01665-09. Epub 2010 Mar 8.

Trends in antimicrobial resistance of Acinetobacter baumannii isolates from a metropolitan Detroit health system

Tara Reddy  1 , Teena Chopra, Dror Marchaim, Jason M Pogue, George Alangaden, Hossein Salimnia, Dina Boikov, Shiri Navon-Venezia, Robert Akins, Philip Selman, Sorabh Dhar, Keith S Kaye
Affiliations

Trends in antimicrobial resistance of Acinetobacter baumannii isolates from a metropolitan Detroit health system

Tara Reddy et al. Antimicrob Agents Chemother. 2010 May.

Abstract

A phenotypic and genotypic analysis of Acinetobacter baumannii was conducted from 2003 to 2008 in Detroit, MI. The incidence of A. baumannii increased from 1.7 to 3.7/1,000 patient days during the study period. Susceptibility to ampicillin-sulbactam and imipenem decreased from approximately 90% to approximately 40%. Genotyping revealed polyclonality, suggesting either emergence of multiple resistant strains or spread of a common genetic element. The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrug-resistant pathogen.

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Figures

FIG. 1.
FIG. 1.
Phylogenetic tree of 27 strains of MDR-AB isolated at DMC during the study period.
FIG. 2.
FIG. 2.
Clone distribution of 25 MDR-AB strains according to REP-PCR.
See this image and copyright information in PMC

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References

    1. Abbo, A., Y. Carmeli, S. Navon-Venezia, Y. Siegman-Igra, and M. J. Schwaber. 2007. Impact of multi-drug-resistant Acinetobacter baumannii on clinical outcomes. Eur. J. Clin. Microbiol. Infect. Dis. 26:793-800. - PubMed
    1. Abbo, A., S. Navon-Venezia, O. Hammer-Muntz, T. Krichali, Y. Siegman-Igra, and Y. Carmeli. 2005. Multidrug-resistant Acinetobacter baumannii. Emerg. Infect. Dis. 11:22-29. - PMC - PubMed
    1. Bassetti, M., E. Righi, S. Esposito, N. Petrosillo, and L. Nicolini. 2008. Drug treatment for multidrug-resistant Acinetobacter baumannii infections. Future Microbiol. 3:649-660. - PubMed
    1. Bou, G., G. Cervero, M. A. Dominguez, C. Quereda, and J. Martinez-Beltran. 2000. PCR-based DNA fingerprinting (REP-PCR, AP-PCR) and pulsed-field gel electrophoresis characterization of a nosocomial outbreak caused by imipenem- and meropenem-resistant Acinetobacter baumannii. Clin. Microbiol. Infect. 6:635-643. - PubMed
    1. Casal, M., F. Rodriguez, B. Johnson, E. Garduno, F. Tubau, R. O. de Lejarazu, A. Tenorio, M. J. Gimenez, R. Bartolome, C. Garcia-Rey, L. Aguilar, and N. Garcia-Escribano. 2009. Influence of testing methodology on the tigecycline activity profile against presumably tigecycline-non-susceptible Acinetobacter spp. J. Antimicrob. Chemother. 64:69-72. - PubMed

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