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Comparative Study
. 2010 May;54(5):2206-8.
doi: 10.1128/AAC.01325-09. Epub 2010 Mar 8.

Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus

Esteban C Nannini  1 , Martin E Stryjewski, Kavindra V Singh, Tom H Rude, G Ralph Corey, Vance G Fowler Jr, Barbara E Murray
Affiliations
Comparative Study

Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus

Esteban C Nannini et al. Antimicrob Agents Chemother. 2010 May.

Abstract

Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.

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