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. 2010 May;54(5):2112-8.
doi: 10.1128/AAC.01418-09. Epub 2010 Mar 8.

Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents

Steven A Rogers  1 , Robert W Huigens 3rd, John Cavanagh, Christian Melander
Affiliations

Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents

Steven A Rogers et al. Antimicrob Agents Chemother. 2010 May.

Abstract

2-aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii.

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Figures

FIG. 1.
FIG. 1.
2-Aminoimidazoles that have antibiofilm and antibiofouling properties.
FIG. 2.
FIG. 2.
(Top) Tetracycline-resistant E. coli. From left to right: E. coli control, E. coli with 50 μM tetracycline, E. coli with 150 μM compound 1, E. coli with 50 μM tetracycline and 150 μM compound 1. (Bottom) MRSA strain BAA-44. From left to right: MRSA control, MRSA with 25 μM methicillin, MRSA with 45 μM compound 1, MRSA with 25 μM methicillin and 45 μM compound 1.
FIG. 3.
FIG. 3.
A 2-aminobenzimidazole that inhibits and disperses Gram-positive biofilms through a zinc-dependent mechanism.
FIG. 4.
FIG. 4.
Metal effects on the ability of compound 1 to inhibit MRSA biofilm formation.
See this image and copyright information in PMC

References

    1. Al Mourabit, A., and P. Potier. 2001. Sponge's molecular diversity through the ambivalent reactivity of 2-aminoimidazole: a universal chemical pathway to the oroidin-based pyrrole-imidazole alkaloids and their palau'amine congeners. Eur. J. Org. Chem. 2001(2):237-243.
    1. Arrizubieta, M. J., A. T. Arana, B. Amorena, J. R. Penades, and I. Lasa. 2004. Calcium inhibits Bap-dependent multicellular behavior in Staphylococcus aureus. J. Bacteriol. 186:7490-7498. - PMC - PubMed
    1. Ballard, T. E., J. J. Richards, A. Aquino, C. S. Reed, and C. Melander. 2009. Antibiofilm activity of a diverse oroidin library generated through reductive acylation. J. Org. Chem. 74:1755-1758. - PubMed
    1. Ballard, T. E., J. J. Richards, A. L. Wolfe, and C. Melander. 2008. Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study. Chemistry 14:10745-10761. - PubMed
    1. Camilli, A., and B. L. Bassler. 2006. Bacterial small-molecule signaling pathways. Science 311:1113-1116. - PMC - PubMed

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