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Comment
. 2010 Mar 16;107(11):4793-4.
doi: 10.1073/pnas.1000736107. Epub 2010 Mar 8.

Leveraging leptin for type I diabetes?

Daniel Kraus  1 , Mark A Herman, Barbara B Kahn
Affiliations
Comment

Leveraging leptin for type I diabetes?

Daniel Kraus et al. Proc Natl Acad Sci U S A. .

Erratum in

  • Proc Natl Acad Sci U S A. 2010 May 11;107(19):8895
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: B.B.K. is on a scientific advisory board for Amylin Pharmaceuticals, Inc.

Figures

Fig. 1
Fig. 1
Insulin, leptin, and the regulation of glucose homeostasis. (A) Plasma insulin levels vary widely in response to meals, whereas glucose is tightly controlled throughout the day (17). Leptin levels fluctuate much less (18). (B) Schematic representation of the convergence of insulin and leptin in a network that regulates glucose homeostasis. Solid lines indicate well-established effects. For clarity, not all connections are depicted. The question marks indicate two proposed interactions. The proposed effect of leptin to suppress glucagon may be direct or indirect. (C) Weighing the potential benefits and risks of leptin treatment for T1DM.
See this image and copyright information in PMC

Comment on

  • Leptin therapy in insulin-deficient type I diabetes.
    Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Charron MJ, Newgard CB, Unger RH. Wang MY, et al. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4813-9. doi: 10.1073/pnas.0909422107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194735 Free PMC article.

References

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    1. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000;62:413–437. - PubMed

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