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Review
. 1977:85B:141-54.
doi: 10.1007/978-1-4615-9038-5_10.

Opiate receptors and endogenous opioid peptides in tolerance and dependence

H W Kosterlitz, J Hughes
Review

Opiate receptors and endogenous opioid peptides in tolerance and dependence

H W Kosterlitz et al. Adv Exp Med Biol. 1977.

Abstract

The impact of the discovery of the endogenous opioid peptides, the enkephalins and endorphins, on our concepts of the mechanisms of tolerance to, and dependence on, opiates is discussed. After a brief survey of the chemistry of the opioid peptides, the possibility of an interaction between opiates and the peptides is considered and a hypothesis formulated. Experimental proof is presented as far as it has become available. The possible mechanisms involved in the development of tolerance and dependence for alcohol, barbiturates and opiates are compared briefly.

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