Review
doi: 10.1016/j.fsigen.2009.09.007.
Epub 2009 Oct 2.
Forensic implications of genetic analyses from degraded DNA--a review
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- PMID: 20215026
- DOI: 10.1016/j.fsigen.2009.09.007
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Review
Forensic implications of genetic analyses from degraded DNA--a review
Forensic Sci Int Genet.
2010 Apr.
Abstract
Forensic DNA identification techniques are principally based on determination of the size or sequence of desired PCR products. The fragmentation of DNA templates or the structural modifications that can occur during the decomposition process can impact the outcomes of the analytical procedures. This study reviews the pathways involved in cell death and DNA decomposition and the subsequent difficulties these present in DNA analysis of degraded samples.
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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