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. 1991 Apr;63(4):522-6.
doi: 10.1038/bjc.1991.124.

Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model

H Yanagië  1 , T Tomita, H Kobayashi, Y Fujii, T Takahashi, K Hasumi, H Nariuchi, M Sekiguchi
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Free PMC article

Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model

H Yanagië et al. Br J Cancer. 1991 Apr.
Free PMC article

Abstract

An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The immunoliposomes attached to tumour cells suppressed growth in vitro upon thermal neutron irradiation and suppression was dependent upon the concentration of the 10B-compound in the liposomes and on the density of antibody conjugated to the liposomes. The results suggest that immunoliposomes containing the 10B-compound could act as a selective and efficient carrier of 10B atoms to target tumour cells in boron neutron-capture therapy.

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References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. J Histochem Cytochem. 1981 Apr;29(4):577-80 - PubMed
    1. Chem Pharm Bull (Tokyo). 1978 Sep;26(9):2619-23 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2492-4 - PubMed
    1. Cancer Res. 1983 Nov;43(11):5328-34 - PubMed

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