Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1991 Apr;63(4):553-60.
doi: 10.1038/bjc.1991.130.

Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance

Affiliations
Free PMC article
Comparative Study

Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance

R A Hawkins et al. Br J Cancer. 1991 Apr.
Free PMC article

Abstract

A method to determine the binding of epidermal growth factor (EGF) to the particulate fraction of the cell has been established and evaluated using rat liver, human placenta, and tumours of human breast and brain. Little EGF receptor (EGFR) activity was detected in normal or benign tumour tissues except for meningioma (positive in 95% samples), but EGFR were present in 43% of 131 breast tumours and 75% of 55 primary cerebral tumours. Despite the strong inverse correlation between EGFR activity and oestrogen receptors in breast tumours and a tendency for high levels of EGFR activity to be associated with glioblastoma multiforme, analysis showed that EGFR was of little prognostic significance in patients with tumours of either breast or brain.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Acta Neuropathol. 1988;77(2):196-201 - PubMed
    1. Eur J Surg Oncol. 1987 Aug;13(4):303-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6899-903 - PubMed
    1. Br J Surg. 1987 Nov;74(11):1009-13 - PubMed
    1. Int J Cancer. 1988 Jul 15;42(1):36-41 - PubMed

Publication types

MeSH terms