Review
doi: 10.4161/cbt.9.9.11511.
Epub 2010 May 12.
The molecular pathogenesis of Ewing's sarcoma
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- PMID: 20215864
- DOI: 10.4161/cbt.9.9.11511
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Review
The molecular pathogenesis of Ewing's sarcoma
Cancer Biol Ther.
.
Free article
Abstract
Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.
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