PEGylated nanocarriers for systemic delivery
- PMID: 20217599
- DOI: 10.1007/978-1-60761-609-2_15
PEGylated nanocarriers for systemic delivery
Abstract
In this chapter, we outline the protocols for PEGylation of some drug carriers, such as dendrimer, polymeric nanoparticles, liposomes, for systemic delivery. PEGylation simply refers to the modification of particle surface by covalently grafting, entrapping, or adsorbing PEG chains of vivid length. However, limitation of simple adsorption being easy displacement of the coating layer in vivo, covalent mode for PEGylation of nanoparticles is mostly preferred, and outlined herein. Derivatization and activation of polyethylene glycol is an important step during PEGylation and its chemistry chiefly relies on availability as well as type of functional groups on carrier periphery. A summarized set of protocols for PEGylation of widely explored nanocarriers for systemic delivery is presented.
Similar articles
-
Method for quantifying the PEGylation of gelatin nanoparticle drug carrier systems using asymmetrical flow field-flow fractionation and refractive index detection.Anal Chem. 2007 Jun 15;79(12):4574-80. doi: 10.1021/ac062135e. Epub 2007 May 17. Anal Chem. 2007. PMID: 17506521
-
PEGylated nanocarriers: A promising tool for targeted delivery to the brain.Colloids Surf B Biointerfaces. 2020 Mar;187:110770. doi: 10.1016/j.colsurfb.2019.110770. Epub 2020 Jan 3. Colloids Surf B Biointerfaces. 2020. PMID: 31926790 Review.
-
PEGylated inorganic nanoparticles.Angew Chem Int Ed Engl. 2011 Feb 25;50(9):1980-94. doi: 10.1002/anie.201002969. Epub 2011 Jan 27. Angew Chem Int Ed Engl. 2011. PMID: 21275011 Review.
-
A preliminary study on MeO-PEG-PLGA-PEG-OMe nanoparticles as intravenous carriers.J Biomed Mater Res A. 2008 Nov;87(2):515-23. doi: 10.1002/jbm.a.31784. J Biomed Mater Res A. 2008. PMID: 18186066
-
PEGylation, successful approach to drug delivery.Drug Discov Today. 2005 Nov 1;10(21):1451-8. doi: 10.1016/S1359-6446(05)03575-0. Drug Discov Today. 2005. PMID: 16243265 Review.
Cited by
-
Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation.Nanoscale. 2013 Sep 21;5(18):8307-8325. doi: 10.1039/c3nr01525d. Nanoscale. 2013. PMID: 23860639 Free PMC article. Review.
-
Tissue engineering of heart valves: PEGylation of decellularized porcine aortic valve as a scaffold for in vitro recellularization.Biomed Eng Online. 2013 Sep 5;12:87. doi: 10.1186/1475-925X-12-87. Biomed Eng Online. 2013. PMID: 24006837 Free PMC article.
-
Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium.Mol Pharm. 2015 Mar 2;12(3):826-38. doi: 10.1021/mp500662z. Epub 2015 Feb 17. Mol Pharm. 2015. PMID: 25455560 Free PMC article.
-
Supramolecular Functionalizable Linear-Dendritic Block Copolymers for the Preparation of Nanocarriers by Microfluidics.Polymers (Basel). 2021 Feb 25;13(5):684. doi: 10.3390/polym13050684. Polymers (Basel). 2021. PMID: 33668750 Free PMC article.
-
Evaluation of Ascorbic Acid Niosomes as Potential Detoxifiers in Oxidative Stress-induced HEK-293 Cells by Arsenic Trioxide.Iran J Pharm Res. 2022 May 17;21(1):e127038. doi: 10.5812/ijpr-127038. eCollection 2022 Dec. Iran J Pharm Res. 2022. PMID: 36710993 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources