Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct 16;8(1):53-7.
doi: 10.2203/dose-response.09-040.Sorensen.

Evolutionary theory and studies of model organisms predict a cautiously positive perspective on the therapeutic use of hormesis for healthy aging in humans

Jesper G Sørensen  1 , Martin Holmstrup, Pernille Sarup, Volker Loeschcke
Affiliations

Evolutionary theory and studies of model organisms predict a cautiously positive perspective on the therapeutic use of hormesis for healthy aging in humans

Jesper G Sørensen et al. Dose Response. .

Abstract

Hormesis, the beneficial effects of mild stress exposures, is a well documented phenomenon in a range of organisms. The documentation mainly relies on relatively simple and controlled laboratory investigations. In order to better understand hormesis and predict the outcome of more complex and realistic conditions, a number of key issues should be investigated in much more detail. One obstacle is the development of precise treatments optimized for single individuals. Only then can we progress with the use of hormesis as a therapeutic tool for humans.

Keywords: Evolution; Multiple Stressors; Sex specific; Stress Response.

PubMed Disclaimer

References

    1. Bindesbøl AM, Holmstrup M, Damgaard C, Bayley M. Stress synergy between environmentally realistic levels of copper and frost in the earthworm Dendrobaena octaedra. Environ Toxicol Chem. 2005;24:1462–1467. - PubMed
    1. Bubliy OA, Loeschcke V. Correlated responses to selection for stress resistance and longevity in a laboratory population of Drosophila melanogaster. J Evol Biol. 2005;18:789–803. - PubMed
    1. Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chlueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettleri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SIS, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol. 2007;222:122–128. - PubMed
    1. Calabrese EJ, Blain RB. Hormesis and plant biology. Environ Pollut. 2009;157:42–48. - PubMed
    1. Forbes VE. Is hormesis an evolutionary expectation? Funct Ecol. 2000;14:12–24.

LinkOut - more resources