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. 2009 Dec 17;73(8):143.
doi: 10.5688/aj7308143.

A receptor-grounded approach to teaching nonsteroidal antiinflammatory drug chemistry and structure-activity relationships

Victoria F Roche  1
Affiliations

A receptor-grounded approach to teaching nonsteroidal antiinflammatory drug chemistry and structure-activity relationships

Victoria F Roche. Am J Pharm Educ. .

Abstract

Objective: To describe a receptor-based approach to promote learning about nonsteroidal anti-inflammatory drug (NSAID) chemistry, structure-activity relationships, and therapeutic decision-making.

Design: Three lessons on cyclooxygenase (COX) and NSAID chemistry, and NSAID therapeutic utility, were developed using text-based resources and primary medicinal chemistry and pharmacy practice literature. Learning tools were developed to assist students in content mastery.

Assessment: Student learning was evaluated via performance on quizzes and examinations that measured understanding of COX and NSAID chemistry, and the application of that knowledge to therapeutic problem solving.

Conclusion: Student performance on NSAID-focused quizzes and examinations documented the success of this approach.

Keywords: medicinal chemistry; nonsteroidal antiinflammatory drugs.

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Figures

Figure 1
Figure 1
2D representations of COX-1 and COX-2 NSAID binding sites.
Figure 2
Figure 2
3D model of the COX-1 and COX-2 NSAID binding site residues.
Figure 3
Figure 3
NSAID structures.
See this image and copyright information in PMC

References

    1. Vane JR, Bakhle S, Botting RM. Cyclooxygenase 1 and 2. Ann Rev Pharmacol Toxicol. 1998;38(April):97–120. - PubMed
    1. Chubb AJ, Fitzgerald DJ, Nolan KB, Moman E. The productive conformation of prostaglandin G2 at peroxidase site of prostaglandin endoperoide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies. Biochemistry. 2006;45(3):811–820. - PubMed
    1. Roche VF. The chemically elegant proton pump inhibitors: A self-contained, clinically relevant medicinal chemistry lesson. Am J Pharm Educ. 2006;70(5) Article 101. - PMC - PubMed
    1. Roche VF. Antihyperlipidemic statins: a self-contained, clinically relevant medicinal chemistry lesson. Am J Pharm Educ. 2005;69(4) Article 77.
    1. Thuresson ED, Lakkides KM, Rieke CJ, et al. Prostaglandin endoperoxide H synthase-1. J Biol Chem. 2001;276(13):10347–10359. - PubMed

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