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. 2010:660:1-4.
doi: 10.1007/978-1-60761-350-3_1.

ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity

Geeta Datta  1 , Manjula Chaddha, Shaila P Handattu, Mayakonda N Palgunachari, Gaurav Nayyar, David W Garber, Himanshu Gupta, C Roger White, G M Anantharamaiah
Affiliations

ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity

Geeta Datta et al. Adv Exp Med Biol. 2010.

Abstract

ApoE mimetic peptide possesses the putative receptor binding domain 141-150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.

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