Protein crystallizability
- PMID: 20221931
- DOI: 10.1007/978-1-60327-241-4_22
Protein crystallizability
Abstract
Obtaining well-diffracting crystals remains a major challenge in protein structure research. In this chapter, we review currently available computational methods to estimate the crystallization potential of a protein, to optimize amino acid sequences toward improved crystallization likelihood, and to design optimal crystal screen conditions.
Similar articles
-
Conformational disorder.Methods Mol Biol. 2010;609:307-25. doi: 10.1007/978-1-60327-241-4_18. Methods Mol Biol. 2010. PMID: 20221927
-
Analysis and prediction of protein quaternary structure.Methods Mol Biol. 2010;609:349-64. doi: 10.1007/978-1-60327-241-4_20. Methods Mol Biol. 2010. PMID: 20221929
-
RFCRYS: sequence-based protein crystallization propensity prediction by means of random forest.J Theor Biol. 2012 Aug 7;306:115-9. doi: 10.1016/j.jtbi.2012.04.028. Epub 2012 May 2. J Theor Biol. 2012. PMID: 22726810
-
Protein secondary structure prediction.Methods Mol Biol. 2010;609:327-48. doi: 10.1007/978-1-60327-241-4_19. Methods Mol Biol. 2010. PMID: 20221928 Review.
-
Prediction of posttranslational modification of proteins from their amino acid sequence.Methods Mol Biol. 2010;609:365-84. doi: 10.1007/978-1-60327-241-4_21. Methods Mol Biol. 2010. PMID: 20221930 Review.
Cited by
-
Protein stability: a crystallographer's perspective.Acta Crystallogr F Struct Biol Commun. 2016 Feb;72(Pt 2):72-95. doi: 10.1107/S2053230X15024619. Epub 2016 Jan 26. Acta Crystallogr F Struct Biol Commun. 2016. PMID: 26841758 Free PMC article. Review.
-
fDETECT webserver: fast predictor of propensity for protein production, purification, and crystallization.BMC Bioinformatics. 2018 Jan 3;18(1):580. doi: 10.1186/s12859-017-1995-z. BMC Bioinformatics. 2018. PMID: 29295714 Free PMC article.
-
Arabinogalactan Proteins Are the Possible Extracellular Molecules for Binding Exogenous Cerium(III) in the Acidic Environment Outside Plant Cells.Front Plant Sci. 2019 Feb 20;10:153. doi: 10.3389/fpls.2019.00153. eCollection 2019. Front Plant Sci. 2019. PMID: 30842782 Free PMC article.
-
Survey of Predictors of Propensity for Protein Production and Crystallization with Application to Predict Resolution of Crystal Structures.Curr Protein Pept Sci. 2018;19(2):200-210. doi: 10.2174/1389203718666170921114437. Curr Protein Pept Sci. 2018. PMID: 28933304 Free PMC article.
-
Critical evaluation of bioinformatics tools for the prediction of protein crystallization propensity.Brief Bioinform. 2018 Sep 28;19(5):838-852. doi: 10.1093/bib/bbx018. Brief Bioinform. 2018. PMID: 28334201 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources