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. 2010 Apr 2;75(7):2289-95.
doi: 10.1021/jo1000687.

Synthesis of acridines by the [4 + 2] annulation of arynes and 2-aminoaryl ketones

Donald C Rogness  1 , Richard C Larock
Affiliations

Synthesis of acridines by the [4 + 2] annulation of arynes and 2-aminoaryl ketones

Donald C Rogness et al. J Org Chem. .

Abstract

The reaction of 2-aminoaryl ketones and arynes generated by the treatment of various o-(trimethylsilyl)aryl triflates with CsF results in [4 + 2] annulation to afford substituted acridines in good yields.

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Figures

Scheme 1
Scheme 1
Proposed Mechanism
See this image and copyright information in PMC

References

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